read:http://www.livestrong.com/article/420615-why-cant-i-take-folic-acid-the-same-day-as-methotrexate/
also this in regard to injections: If it is single dose then room temperature. DO NOT, reuse after initially piercing the septum. Multi dose vials have preservatives that inhibit bacterial growth. Single dose doesn't, so it isn't safe to save the vi
Here is some comments on it: "At first I did have some nausea and flu like symptoms so my dr divided my dose over two nights. After about a month my body adjusted so I now take it at night around 9 PM and make sure I have something to eat like a banana or yogurt. I rarely suffer from any side effects. Once in a while I'll wake up with a little nausea but it is not a problem."
see also : https://www.arthritis.org/living-with-arthritis/treatments/medication/side-effects/understanding-medication-risks.php?utm_source=enewsletter&utm_medium=at&utm_campaign=183
also https://www.arthritis.org/living-with-arthritis/treatments/medication/drug-guide/?utm_source=enewsletter&utm_medium=at&utm_campaign=183
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